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Category Impotence
Sildenafil (Viagra) is approved for the treatment of
impotence (also known as erectile dysfunction). It was the first oral medication for this purpose.
What are the causes of impotence? How does Viagra affect
erection? Are there side effects and drug interactions?
Read on...
Impotence is a consistent inability to sustain an
erection sufficient for sexual intercourse. Impotence can
be a total inability to achieve erection, an inconsistent
ability to do so, or a tendency to sustain only brief
erections. Incidence rises with age: about 5 percent of men
at the age of 40 and between 15 and 25 percent of men at
the age of 65 experience impotence. Yet, it is not an
inevitable part of aging.
Medical professionals often use the term "erectile
dysfunction" to describe impotence. Impotence and erectile
dysfunction should be distinguished from other conditions
that interfere with sexual intercourse, such as lack of
sexual desire and problems with ejaculation and orgasm.
Damage to arteries, smooth muscles, and nerves of the penis
can lead to impotence. One common cause of impotence is
blood vessel and nerve damage due to diabetes mellitus.
Other causes of impotence include low testosterone levels,
kidney disease, chronic alcoholism, multiple sclerosis (a
disease of the nervous system), atherosclerosis (leading to
blood vessel hardening), surgical damage to nerves and
blood vessels (for example, prostate surgery), and injury
to the penis, bladder, pelvis and the spinal cord.
Some common medicines produce impotence as a side effect.
These include certain high blood pressure drugs,
antihistamines, antidepressants, tranquilizers, appetite
suppressants, and cimetidine (an ulcer drug). Smoking
affects blood flow in veins and arteries, and is also
believed to lead to impotence.
Psychological factors such as stress, anxiety, guilt,
depression, low self-esteem, and fear of sexual failure are
associated with impotence.
If the underlying condition leading to impotence cannot be
corrected, or if impotence problems persist, medications
can help certain men achieve erection sufficient for sexual
Intercourse as well as maintain erection after penetration.
The penis contains two chambers, called the corpora
cavernosa, which run the length of the organ. Erection
begins with sensory and mental stimulation. Impulses from
the brain and local nerves cause the muscles of the corpora
cavernosa to relax, allowing blood to flow in and fill the
chambers. The inflow of blood creates pressure in the
corpora cavernosa chambers, making the penis expand.
Erection is reversed when muscles in the penis contract,
stopping the inflow of blood and causing the blood in the
chambers to flow out.
Cyclic guanosine monophosphate (cGMP), a signaling molecule within
cells, tells the smooth muscle in the corpora cavernosa to relax and
this lets blood flow into the chambers and be trapped for an
erection.
The erection is lost when cGMP is degraded by an enzyme (PDE5),
lowering the level of cGMP, so the muscle of the corpus cavernosa
contracts again, the blood flows out of the chambers of the corpus
cavernosa and the erection is no more.
Sildenafil (Viagra) is an oral agent recently approved by
the United States FDA for the treatment of erectile
dysfunction. Its major mode of action is inhibition of the
enzyme PDE5. Inhibiting this enzyme allows the cyclic GMP
to stay around longer, thus maintaining erection. Viagra is
not an aphrodisiac, it is not effective without sexual
stimulation. It mainly enhances the normal physiologic
erection.
Clinical trials using Viagra have been conducted in
patients with vascular diseases, diabetes mellitus, spinal
cord injuries, psychogenic causes, and after radical
prostrate surgery. Some 70%-80% of men reported improved
quality of their erections. Over 50% of patients were able
to have successful vaginal penetration using Viagra.
Viagra is administered orally one hour prior to the
anticipated sexual activity, preferably on an empty
stomach. The absorption of Viagra can be decreased by a
fatty meal.
Viagra is eliminated mainly by the cytochrome p450 system
in the liver. Elderly men and men with liver or kidney
dysfunction have reduced ability to eliminate the drug.
Therefore, these patients should start with the lowest dose
(25 mg) to avoid problems with toxicity. Medications that
interfere with cytochrome p 450 (such as erythromycin,
cimetidine, and ketoconazole) can also decrease the
elimination of Viagra. These other medications should
preferably be stopped when using Viagra, or Viagra should
be used cautiously starting with the lowest dose.
Viagra used alone can cause mild drop in blood pressure.
But it should NOT be used together with nitrates
nitroglycerin, isordil, and other related preparations)
because of significant low blood pressure (hypotension)
that can develop.
Side effects are dose related. Headaches were noted in 16%,
flushing 10%, dyspepsia 7%, and abnormal vision
(disturbance in blue/green color discrimination) 3%. |
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Cialis
Cialis (TADALAFIL) is an oral drug,
used for treating male impotence, also known as erectile men's
erectile dysfunction. Clinical studies show that Cialis works
faster, lasts up to 36 hours and has less side effects than
Viagra.
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Brand
Viagra
Brand Viagra (Sildenafil) - pills
made by Phizer, is an oral medication for erectile dysfunction
(ED). It helps most men with ED improve their erections. That
means they are able to achieve harder erections.
Maintaining an erection is just as...
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Brand
Cialis
Brand Cialis (TADALAFIL), dubbed
"Le Weekend Drug" in Europe, is a new treatment for Erectile
Dysfunction (ED) from Lilly ICOS LLC. Clinical studies show
that Cialis works faster, lasts up to 36 hours and has less
side effects than Viagra.
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Viagra
Professional
Unlike previously approved
treatments for impotence, Viagra does not directly cause penis
erection, but affects the response to sexual stimulation. The
drug acts by enhancing smooth muscle relaxation using nitric
oxide, a chemical that is normally...
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Cialis
Professional
Cialis Professional (Tadalafil) is
newly formulated and chemically improved prescription medicine
has proved to be useful for multiplied orgasm and increased
penis size. This medicine needs to be taken 20-30 minutes
before a sexual activity and...
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Viagra
Super Active
Viagra Super Active (SILDENAFIL) is
a new therapy for the treatment of erectile dysfunction. This
super-active formulation gives the pill the quickest level of
absorption, most intense effect on chemical messengers within
the tissues of the penis...
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Cialis
Super Active
Cialis Super Active (TADALAFIL) is
a newly formulated and chemically improved medicine for the
treatment and cure the overall whelming disease of erectile
dysfunction. Super-active formulation gives the pill the
shortest activation time, most...
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Cialis
Soft
Generic Cialis Soft (TADALAFIL
SOFT) is a phosphodiesterase inhibitor used for the treatment
of men's erectile dysfunction. Soft Tabs are rapid action
Cialis solutions. A Soft Tab is an oral lozenge, mint in
flavor, containing pure Tadalafil...
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Viagra
Soft
Sildenafil (Viagra) Citrate are the
revolutionary treatment drugs for men suffering from Erectile
Dysfunction (ED). Similar to Viagra, they contain similar
chemical compounds, but unlike other drugs that are swallowed
& digested, these are...
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Viagra
Soft 10 pills x 100 mg + Cialis Soft 10 pills x 20 mg
Viagra Soft(Sildenafil
Citrate Soft) has revolutionized the way physicians treat men
suffering from erectile dysfunction (ED). For the first time,
a potent oral medication is available that is able to markedly
improve sexual activity in...
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Viagra
10 pills x 100 mg + Cialis 10 pills x 20 mg
Viagra (Sildenafil)
It
has been estimated that impotence affects 140 million men
worldwide. Over half of all men with impotence are thought to
have some physical (medical) cause. The remainder are believed
to have psychogenic causes...
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Viagra
10 pills x 100 mg + Cialis 10 pills x 20 mg + Levitra 10 pills
x 20 mg
Viagra (Sildenafil) It has
been estimated that impotence affects 140 million men
worldwide. Over half of all men with impotence are thought to
have some physical (medical) cause. The remainder are believed
to have psychogenic causes of...
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Viagra
Oral Jelly
Viagra (Sildenafil) Citrate has
revolutionized the way physicians treat men suffering from
erectile dysfunction (ED). For the first time, a potent oral
medication is available that is able to markedly improve
sexual activity in over 80% of men...
Our rating:
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Viagra
30 pills x 100 mg + Cialis 10 pills x 20 mg
Viagra (Sildenafil) It has
been estimated that impotence affects 140 million men
worldwide. Over half of all men with impotence are thought to
have some physical (medical) cause. The remainder are believed
to have psychogenic causes of...
Our rating:
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Viagra
Capsules
Viagra Capsules (SILDENAFIL) is an
oral drug for male impotence, also known as erectile
dysfunction. Viagra has a great safety track record and proven
effects that start acting in 30 minutes to 1 hour and last for
about 4 hours.
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Viagra
Flavored
Viagra Flavored (SILDENAFIL) in
amazing flavored chewable tablets – banana, orange, pineapple
and strawberry! Works in 5-15 minutes compared to 0.5-1 hour
for the regular pills. We provide the highest quality
generics.
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Levitra
Generic Levitra (VARDENAFIL) is one
of the latest treatments for Erectile Dysfunction. Levitra
acts in the same way as Viagra by blocking an enzyme called
PDE-5. Clinical studies show that Levitra works faster and has
less side effects than Viagra
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Brand
Levitra
Brand Levitra (VARDENAFIL) is one
of the latest treatments for Erectile Dysfunction. Levitra
acts in the same way as Viagra by blocking an enzyme called
PDE-5. Clinical studies show that Levitra works faster and has
less side effects than Viagra
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Penisol
Penisol is the most effective &
well known herbal penis enlargement pills ever made.
Penisol uses perfectly blended 100% NATURAL HERBAL,
doctors and herbs lists approved
ingredients variation
that has proven in clinical trials to...
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Avodart
Avodart is used for treating
conditions as determined by your doctor.It is also used to
treat symptoms of benign prostatic hyperplasia (BPH or
enlargement of the prostate gland) and to reduce the risk of
urinary blockage and the need for prostate...
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Flomax
Flomax is used for treating
enlarged prostate (benign prostatic hyperplasia; BPH).It may
also be used for other conditions as determined by your
doctor.
Flomax is an alpha-blocker. It works by
relaxing muscles in the prostate and...
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Proscar
Proscar (FINASTERIDE) prevents the
conversion of testosterone to dihydrotestosterone (DHT) in the
body. DHT is involved in the development of benign prostatic
hyperplasia (BPH).
Proscar is used to treat symptoms of
benign prostatic...
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Silagra
Silagra (SILDENAFIL CITRATE) is
designed to function by broadening or expanding the arteries
in the male penis enabling the blood to flow at the higher
rate, promoting the penis to erect harder enough for providing
heavenly pleasure to the couple...
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Caverta
Caverta (SILDENAFIL CAVERTA) is a
tablet used to treat erectile dysfunction (impotence) in men.
It can help men who have erectile dysfunction get and sustain
an erection when they are sexually excited. One does not get
an erection just by taking...
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Kamagra
Kamagra (SILDENAFIL CITRATE) is the
first of a new group of medication which allows adequate
sexual stimulation, relaxes the blood vessels of the penis and
helps erection.
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Confido
Confido is a non-hormonal therapy
acting on the higher centers of emotions in the brain and
locally on the sex organs directly or indirectly. Confido
reduces anxiety and calms the individual. By acting through
the neuro-endocrine pathway, Confido...
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Dutas
Dutas (DUTASTERIDE) is used for the
treatment of symptomatic benign prostatic hyperplasia (BPH) in
men with an enlarged prostate.
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Himcolin
Himcolin is a local rub for Men
that increases staying power and intensity, resulting in
maximum pleasure. Himcolin also has soothing and moisturising
properties.
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Himplasia
Himplasia is a non-hormonal herbal
medicine that reduces risks for prostate, helps to maintain
its health and supports male fertility and reproductive
function.
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Lasuna
Lasuna (GARLIC) is a nerve
stimulant and revigorating tonic that has been known for its
value in cases of sexual weakness.
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Speman
Speman tablet is useful in
oligospermia.
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Tadalis
SX
Tadalis SX is a phosphodiesterase
inhibitor used to treat sexual function problems such as
impotence or erectile dysfunction. In combination with sexual
stimulation, Tadalis SX works by helping the blood flow into
the penis to achieve and maintain...
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Tentex
Forte
Tentex Forte is a non-hormonal and
safe sexual stimulant. It has been proven effective in cases
of sexual weakness, without the side effects, usually
associated with testosteron therapy.
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Tentex
Royal
Tentex Royal corrects erectile
dysfunction by relaxation of the cavernosal muscles resulting
in increase in penile blood flow.
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Kamagra
Flavored
Kamagra Flavored (SILDENAFIL) is
unique in that it increases a natural occurring process,
therefore, only through sexual stimulation will an erection
occur.
Our new Chewable Kamagra Soft-Tabs come in
multi-flavour packs. Flavours include...
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Apcalis
SX
Apcalis SX (Cialis, Generic
Tadalafil) - is manufactured by Ajantha Pharma, India.
Tadalafil is used to treat male sexual function problems
(impotence or erectile dysfunction) by blocking a certain
enzyme (phosphodiesterase-PDE5) in the body. In...
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Apcalis
SX Oral Jelly (Orange flavor)
Apcalis SX Oral Jelly (Cialis,
Generic Tadalafil) - is manufactured by Ajantha Pharma, India.
It is used for impotence, loss of libido and Erectile
Dysfunction or Ed treatment in man. Apcalis tadalafil Oral
jelly is the jelly form (Orange flavor).
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Penegra
Penegra (Sildenafil) is an oral
therapy for Impotence containing Sildenafil Citrate, similar
active ingredient as in its braned version. Manufactured by
Zydus Cadila Penegra meets the strictest guidelines set by the
World Health Organisation....
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Forzest
Forzest (Tadalafil) launched by
Ranbaxy, is used to treat erectile dysfunction (impotence) in
men. Forzest tadalafil tablets can help men who have erectile
dysfunction get and sustain an erection when they are sexually
excited. It is available in...
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Tadacip
Tadacip (Tadalafil) is manufactured
by Cipla Ltd in India and its the Generic Version of Cialis
20mg by Lilly.
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VPXL
VPXL is designed to enlarge your
penis size and works on both circumcised and non circumcised
penis. VPXL is manufactured in USA, each bottle contains 60
capsules.
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Acai
Berry
Cloud Nine Acai Berry includes only
the highest grade Acai powder available. This is seen and felt
in how our Acai powerful cleansing formula helps you to lose
weight and feel great all day long. Cloud9 Acai will help you
to rid your body of...
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 Loraine
(Albany, New York) - When my husband was denied Medicare for his
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visit our Grandchildren. Thanks to your company we were able to find
the reasonably priced medication he needed and we could still afford
the trip...
Mike
(Dallas, Texas) - When it was determined that my shipment was
lost in the mail, your support staff did not hesitate to ship me a
new prescription right away. I was very impressed with the level of
MedrugsPlus integrity and professionalism...
Some common medicines produce impotence as a side effect.
These include certain high blood pressure drugs,
antihistamines, antidepressants, tranquilizers, appetite
suppressants, and cimetidine (an ulcer drug). Smoking
affects blood flow in veins and arteries, and is also
believed to lead to impotence.
Psychological factors such as stress, anxiety, guilt,
depression, low self-esteem, and fear of sexual failure are
associated with impotence.
If the underlying condition leading to impotence cannot be
corrected, or if impotence problems persist, medications
can help certain men achieve erection sufficient for sexual
Intercourse as well as maintain erection after penetration.
The penis contains two chambers, called the corpora
cavernosa, which run the length of the organ. Erection
begins with sensory and mental stimulation. Impulses from
the brain and local nerves cause the muscles of the corpora
cavernosa to relax, allowing blood to flow in and fill the
chambers. The inflow of blood creates pressure in the
corpora cavernosa chambers, making the penis expand.
Erection is reversed when muscles in the penis contract,
stopping the inflow of blood and causing the blood in the
chambers to flow out.
Cyclic guanosine monophosphate (cGMP), a signaling molecule within
cells, tells the smooth muscle in the corpora cavernosa to relax and
this lets blood flow into the chambers and be trapped for an
erection.
The erection is lost when cGMP is degraded by an enzyme (PDE5),
lowering the level of cGMP, so the muscle of the corpus cavernosa
contracts again, the blood flows out of the chambers of the corpus
cavernosa and the erection is no more.
Sildenafil (Viagra) is an oral agent recently approved by
the United States FDA for the treatment of erectile
dysfunction. Its major mode of action is inhibition of the
enzyme PDE5. Inhibiting this enzyme allows the cyclic GMP
to stay around longer, thus maintaining erection. Viagra is
not an aphrodisiac, it is not effective without sexual
stimulation. It mainly enhances the normal physiologic
erection.
Clinical trials using Viagra have been conducted in
patients with vascular diseases, diabetes mellitus, spinal
cord injuries, psychogenic causes, and after radical
prostrate surgery. Some 70%-80% of men reported improved
quality of their erections. Over 50% of patients were able
to have successful vaginal penetration using Viagra.
Viagra is administered orally one hour prior to the
anticipated sexual activity, preferably on an empty
stomach. The absorption of Viagra can be decreased by a
fatty meal.
Viagra is eliminated mainly by the cytochrome p450 system
in the liver. Elderly men and men with liver or kidney
dysfunction have reduced ability to eliminate the drug.
Therefore, these patients should start with the lowest dose
(25 mg) to avoid problems with toxicity. Medications that
interfere with cytochrome p 450 (such as erythromycin,
cimetidine, and ) can also decrease the
elimination of Viagra. These other medications should
preferably be stopped when using Viagra, or Viagra should
be used cautiously starting with the lowest dose.
Viagra used alone can cause mild drop in blood pressure.
But it should NOT be used together with nitrates
(nitroglycerin, isordil, and other related preparations)
because of significant low blood pressure (hypotension)
that can develop.
Side effects are dose related. Headaches were noted in 16%,
flushing 10%, dyspepsia 7%, and abnormal vision
(disturbance in blue/green color discrimination) 3%.
Last Editorial Review: 12/29/2004
|
